Search on: MAP KINASE KINASE KINASES 
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Descriptor English:   MAP Kinase Kinase Kinases 
Descriptor Spanish:   Quinasas Quinasa Quinasa PAM 
Descriptor Portuguese:   MAP Quinase Quinase Quinases 
Synonyms English:   MAPK-ERK Kinase Kinases
MAPKKKs
MEK Kinases
MEKKs  
Tree Number:   D08.811.913.696.620.682.700.559
D12.644.360.400
D12.776.476.400
Definition English:   Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). 
See Related English:   MAP Kinase Signaling System
 
History Note English:   2000; use MAP KINASE KINASE KINASE (1992-1999) 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   34448 
Unique Identifier:   D020930 

Occurrence in VHL: 		 

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